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Guanfacine

Guanfacine
Guanfacine
Product Description
Guanfacine (brand name Tenex, and the extended release Intuniv) is a sympatholytic. It is a selective receptor agonist. These receptors are concentrated heavily in the prefrontal cortexand the locus coeruleus, with the potential to improve attention abilities via modulating post-synaptic receptors in the prefrontal cortex. Guanfacine lowers both systolic and diastolicblood pressure by activating the central nervous system 2a norepinephrine autoreceptors, which results in reduced peripheral sympathetic outflow and thus a reduction in peripheralsympathetic tone. Its side-effects are dose dependent, with practically no dryness of the mouth at doses of 2 mg and less
 

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